By Alok A. Khorana, Charles W. Francis
Showcasing the services of top-tier experts who contributed to the newly published instructions for the care of thrombosis in melanoma sufferers, this intriguing advisor used to be written and edited by way of participants of the yank Society of medical Oncology panel, (ASCO), at the prevention and remedy of cancer-associated thrombosis, between others, and gives an authoritative dialogue of techniques to successfully enforce and interpret the hot ASCO/NCCN directives. status because the in simple terms up to date resource to conveniently research intriguing new translational technology findings concerning the biology of cancer-associated thrombosis, in addition to new scientific suggestions, this consultant provides an authoritative and present dialogue of the mechanisms, administration, and prevention of cancer-associated thrombosis.
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Extra info for Cancer-Associated Thrombosis: New Findings in Translational Science, Prevention, and Treatment
FEBS Lett 1996; 390:334–338. 24. Shoji M, Hancock WW, Abe K, et al. Activation of coagulation and angiogenesis in cancer. Immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer. Am J Pathol 1998; 152:399–411. 25. Callander NS, Varki N, Rao LVM. Immunohistochemical identification of tissue factor in solid tumors. Cancer 1992; 70:1194–1201. 26. Vrana JA, Stang MT, Grande JP, et al. Expression of tissue factor in tumor stroma correlates with progression to invasive human breast cancer: paracrine regulation by carcinoma cell-derived members of the transforming growth factor β Family.
In contrast, no apparent developmental defects in the vasculature result from deletion of PAR2. There are several mechanisms by which PAR1 signaling can influence endothelial function in angiogenesis, including regulation of TGF-β receptor internalization (82), attenuation of endothelial cell proliferation (83), and regulation of endothelial progenitor cell differentiation (84,85). Thrombin supports tumor or endothelial cell survival and proliferation (86), but TF and KHORANA Hemostasis and Angiogenesis R2 08/30/07 Chapter 02 23 PAR2 signaling can induce similar cellular effects (71,87–89).
Phage display screening has recently identified tumor stroma–homing peptides that require both fibronectin and fibrin deposition for binding, demonstrating that fibrin– fibronectin complexes are an important component of tumor stroma (42). FXIII directly and indirectly, through α2-antiplasmin cross-linking, counteracts fibrin degradation and thus stabilizes the transitional matrix of the tumor microenvironment (43). Indeed, FXIII has proangiogenic effects and FXIII-deficient mice display reduced angiogenesis and wound healing.