Download Bacteriophages: Biology and Applications by Alexander Sulakvelidze, Elizabeth Kutter PDF

By Alexander Sulakvelidze, Elizabeth Kutter

According to the emergence of pathogenic micro organism that can not be handled with present antibiotics, many researchers are revisiting using bacteriophages, or phages, to struggle multidrug-resistant micro organism. Bacteriophages: Biology and functions presents extraordinary, complete info on bacteriophages and their purposes, equivalent to phage remedy. It deals thoughts, media, and technique interested in setting apart and dealing with healing phages. images, line drawings, and electron micrographs of phages also are incorporated. With its large process, this booklet is an invaluable reference for microbiologists, hematologists, and infectious ailment researchers.

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L. , The growth of bacteriophage, J Gen Physiol, 22, 365–384, 1939. Emmerich, R. , Die künstliche Darstellung der immunisierenden Substanzen (Nucleasen-Immunproteïdine) und ihre Verwendung zur Therapie der Infektionskrankheiten und zur Schutzimpfung and Stelle de Heilserums, Zeitsch f Hyg u Infektionskrankh, 36, 9, 1901. , Biochemical Studies of Bacterial Viruses, University of Chicago Press, Chicago, IL, 1952. P. , Thinking about Science: Max Delbrück and the Origins of Molecular Biology, Norton, New York, 1988.

7. Relatively little is known about most of the others, which generally have been isolated under extremes of pH, temperature, or salinity and have only been observed in Archaea. 32 Bacteriophages: Biology and Applications Phages can also be divided into two classes based on lifestyle: virulent or temperate. Virulent phages can only multiply by means of a lytic cycle; the phage virion adsorbs to the surface of a host cell and injects its genome, which takes over much of host metabolism and sets up molecular machinery for making more phages.

These observations suggested that there is a dissociation of the “membranous ghosts” of the phage from Bacteriophage Research: Early History 19 the DNA component as one of the steps in phage reproduction. Turning their attention to adsorption of phage to intact bacteria rather than bacterial debris, they wrote: Anderson (1951) has obtained electron micrographs indicating that phage T2 attaches to bacteria by its tail. If this precarious attachment is preserved during the progress of the infection, and if the conclusions reached above are correct, it ought to be a simple matter to break the empty phage membranes off the infected bacteria, leaving the phage DNA inside the cells.

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