By Shaker A. Mousa
1This choice of evaluate articles highlights the most recent improvement of antithrombotics and gives confirmed experimental tools for the extra improvement of latest and more desirable anticoagulants. one of the state of the art advancements reviewed are the radical utilization of low molecular weight heparins, such antithrombin brokers because the hirudin, and such antiplatelet medicines because the GPIIb/IIIa inhibitors and ADP receptor antagonists. extra ideas mentioned contain aspirin and clopidogrel, the accelerated use of polytherapeutic techniques, antiproteases (factors IIa, Xa, and VIIa), tissue issue focusing on, platelet receptor focusing on, and antithrombin III modulation.
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Additional info for Anticoagulants, Antiplatelets, and Thrombolytics (Methods in Molecular Medicine)
Grines, C. , Cox, D. , et al. (2002) Comparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction. N. Engl. J. Med. 346, 957–966. 22. The SPEED Group (Strategies for the Patency Enhancement in the Emergency Department) (2001) Randomized trial of abciximab with and without low-dose reteplase for acute myocardial infarction. Circulation 101, 2788–2794. 23. Antman, E. , Gibson, C. , de Lemos, J. , et al. (2000) Combination reperfusion therapy with abciximab and reduced dose reteplase: results from TIMI 14.
Prog. Hemostasis Thromb. 6, 139–177. 7. The EPIC Investigators (1994) Use of a monoclonal antibody directed against the glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. N. Engl. J. Med. 330, 956–961. 8. Konstantopoulos, K. and Mousa, S. A. (2001) Antiplatelet therapies: platelet GPIIb/IIIa antagonists and beyond. Current Opinion in Investigational Drugs 2, 1086–1092. 9. Mousa, S. A. (1999) Antiplatelet therapies: recent advances in the development of platelet GPIIb/IIIa antagonists, in Current Interventional Cardiology Reports, Vol.
Lancet 358, 605–613. 20. White, H. and the HERO-2 Investigators (2001) Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomized trial. Lancet 358, 1855–1863. 21. Stoen, G. , Grines, C. , Cox, D. , et al. (2002) Comparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction. N. Engl. J. Med. 346, 957–966. 22. The SPEED Group (Strategies for the Patency Enhancement in the Emergency Department) (2001) Randomized trial of abciximab with and without low-dose reteplase for acute myocardial infarction.