By Andrew Hadley, Peter Soothill
The potent prevention, analysis, and administration of alloimmune cytopenias has turn into a group attempt related to hematologists, obstetricians, pediatricians, immunologists, laboratory technicians, midwives, and learn scientists. This e-book has been written by way of specialists of their respective fields to assemble the problems of pathogenesis, epidemiology, prevention, analysis, and scientific administration. This accomplished yet available account is broadly cross-referenced to stress the hyperlinks among pathogenesis and medical sequels, among epidemiology and the reason for screening courses, and among analysis and healing intervention.
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Additional info for Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn
The prevention of Rh immunisation. Transfusion Medicine Reviews, 2, 129–50. 9 Woodrow JC (1970). Rh immunization and its prevention. Series Haematologica, 3, 1–151. 10 Queenan JT (1982). Amniocentesis and isoimmunization. In Rh Hemolytic Disease. New Strategy for Eradication, eds. FD Frigoletto, JF Jewette & AA Kongugres. Boston, MA: Hall Medical, pp. 125–34. 11 Grant CJ, Hamblin TJ, Smith DS & Wellstead L (1983). Plasmapheresis in Rh hemolytic disease, the danger of amniocentesis. International Journal of Artiﬁcial Organs, 6, 83–6.
American Journal of Obstetrics and Gynecology, 154, 1327–32. 54 Hadley AG, Kumpel BM, Leader KA, Poole GD & Fraser ID (1991). Correlation of serological, quantitative and cell-mediated functional assays of maternal alloantibodies with the severity of haemolytic disease of the newborn. British Journal of Haematology, 77, 221–8. 55 Garner SF, Weiner E, Contreras M et al. (1992). Mononuclear phagocyte assays, AutoAnalyzer quantitation and IgG subclasses of maternal anti-RhD in the prediction of the severity of haemolytic disease in the fetus before 32 weeks gestation.
2 The immune destruction of fetal red cells Despite a wealth of in vitro data, it is unclear which of the Fc␥ receptors are involved in the immune destruction of sensitized cells. 45 However, a role for Fc␥ receptor I in vivo seems unlikely because interactions between anti-D-sensitized red cells and this high aﬃnity receptor are blocked by IgG concentrations several orders of magnitude lower than those found in plasma. Fc␥ receptor IIa has a very low aﬃnity for IgG1 and IgG3 and seems unlikely to play a role in the destruction of red cells sensitized with these subclasses.