Download ABC of Clinical Haematology by Drew Provan PDF

By Drew Provan

Overlaying hematological facets of parts akin to pathology, molecular technological know-how, melanoma, and normal drugs, this consultant turns out to be useful as a reference for basic perform and health center employees, hematologists and trainees in hematology. This moment version displays advances within the figuring out of the molecular biology of affliction because the first variation used to be released in 1998. Provan teaches within the division of Hematology at Queen Mary's college of drugs and Dentistry.

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Yin J, Wheatley K, Rees J, Burnett A on behalf of the UK MRC Adult Leukaemia Working Party. Comparison of ‘sequential’ versus ‘standard’ chemotherapy as re-induction treatment, with or without cyclosporine, in refractory/relapsed AML: results of the UK MRC AML-R trial. Br J Haematol 2001;113:713-26. Sievers E, Larson R, Stadtmauer E et al. for the Mylotarg Study Group. Efficacy and safety of Mylotarg (gemtuzumab ozogamicin) in patients with CD33-positive acute myeloid leukemia in first relapse.

The anaemia is a normochromic, normocytic anaemia, and the thrombocytopenia may be severe (platelet count Ͻ10 ϫ 109/l). Coagulation screening may yield abnormal results, particularly in promyelocytic leukaemia (acute myeloid leukaemia M3) when granules from the leukaemic blasts can have procoagulant activity and trigger a consumptive coagulopathy. Biochemical screening is particularly important if the leucocyte count is very high, when there may be evidence of renal impairment and hyperuricaemia.

The development of peripheral rather than bone marrow stem cell harvest has reduced procedural mortality. The principle of dose intensity suggests that higher doses of chemotherapy will reduce relapse risk. Autologous transplantation involves stem cell rescue (with patients’ own cells harvested in remission) after a potentially lethal dose of chemotherapy. Ongoing large scale clinical trials are studying the benefit of this modality over conventional treatment. The concept of allogeneic transplantation—where healthy stem cells from a sibling or unrelated donor are given to replace diseased marrow—has always been appealing.

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